Rabbit Hemorrhagic Disease Virus (RHDV2)

RHDV2 is a highly contagious and deadly virus that affects both wild and domestic rabbits. While it does not pose a threat to humans or other pets, it is often fatal to rabbits, including wild cottontails and other lagomorphs like pikas.

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What You Need to Know:

• Prior to 2020, RHDV outbreaks were rare and contained.

• In 2020, a major outbreak began in the Southwest U.S. and rapidly spread.

• The disease is now endemic in Colorado.
   

Vaccination Is Critical

We strongly recommend vaccinating your pet rabbits against RHDV2.

• The vaccine requires an initial two-dose series, followed by
  annual boosters.

• Talk to your rabbit-savvy vet to schedule vaccinations.
   

Practice Good Biosecurity

Even if your rabbit is vaccinated, biosecurity helps reduce risk:

• Keep rabbits indoors (recommended for many reasons).

• No outdoor playtime or foraging.

• Remove shoes before entering your home.

• Wash hands before and after handling your rabbits.

• Quarantine any new rabbits before introducing them to others.
   

Know the Symptoms

RHDV2 often strikes suddenly, and some rabbits may die without showing any signs. When symptoms do appear, they may include:

• Loss of appetite

• Lethargy

• High fever

• Seizures

• Jaundice

• Bleeding (nose, mouth, or rectum)

• Difficulty breathing

• Sudden death
   

Any unexpected rabbit death should be treated as a potential RHDV case—contact your veterinarian immediately.